Association between high-mobility group box 1 and neonatal respiratory distress syndrome.
- Author:
Wen-Xiu WANG
1
;
Bo CHEN
;
Wei ZHANG
;
Hui-Rong ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Female; HMGB1 Protein; blood; Humans; Infant, Newborn; Male; Prognosis; Respiratory Distress Syndrome, Newborn; blood; diagnosis
- From: Chinese Journal of Contemporary Pediatrics 2017;19(4):398-401
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the association between serum level of high-mobility group box 1(HMGB1) and neonatal respiratory distress syndrome (NRDS).
METHODSA total of 35 infants with NRDS and 35 normal neonates (control group) were enrolled. Peripheral venous blood samples were collected with 12-24 hours after birth. ELISA was used to measure the serum level of HMGB1.
RESULTSThe infants with mild and severe NRDS had a significantly higher serum level of HMGB1 than the control group (P<0.05). The infants with severe NRDS had a significantly higher serum level of HMGB1 than those with mild NRDS (P<0.05). The infants with NRDS who died had a significantly higher serum level of HMGB1 than those who survived (P<0.05). The receiver operating characteristic (ROC) curve showed that the optimal cut-off value for serum level of HMGB1 to predict NRDS was 625.3 pg/mL with an area under the ROC curve (AUC) of 0.846 (95%CI: 0.755-0.936), and the optimal cut-off value for serum level of HMGB1 to predict the death of infants with NRDS was 772.2 pg/mL with an AUC of 0.916 (95%CI: 0.813-1.000).
CONCLUSIONSInfants with NRDS have a significant increase in the serum level of HMGB1, and the serum level of HMGB1 can well predict the development and prognosis of NRDS.
