Effect of berberine in treating type 2 diabetes mellitus and complications and its relevant mechanisms.
- Author:
Qing ZHANG
;
Yan LI
;
Lei CHEN
- Publication Type:Journal Article
- MeSH:
Animals;
Berberine;
administration & dosage;
Blood Glucose;
metabolism;
Diabetes Complications;
drug therapy;
metabolism;
Diabetes Mellitus, Type 2;
drug therapy;
metabolism;
Drugs, Chinese Herbal;
administration & dosage;
Humans
- From:
China Journal of Chinese Materia Medica
2015;40(9):1660-1665
- CountryChina
- Language:Chinese
-
Abstract:
Berberine (BBR) is a type of alkaloids isolated from Coptidis Rhizoma and Phellodendri Chinensis Cortex and has been used to treat bacterial gastroenteritis, diarrhea and other digestive diseases for more than 1 000 years. According to recent studies, berberine has been found to have multiple pharmacological activities, including lowering blood glucose and lipid, anti-inflammation, antioxidation, relieving type 2 diabetic nephropathy (DN), diabetic cardiovascular disease, diabetic peripheral neuropathy ( DPN) and other complications. In this article, the authors summarized the literature reports about the effects of BBR in lowering blood glucose and preventing and treating the above type 2 diabetes and its complications, in order to provide reference to further studies and promotion of BBR's application.
