Preparation and evaluation of novel mesoporous molecular sieve of baicalin surface molecularly imprinted polymers.
- Author:
Xia-li GU
;
Hong-liang HE
;
Li-ying SHI
;
Yan-kun GAO
;
Li-na CHEN
- Publication Type:Journal Article
- MeSH:
Adsorption;
Drugs, Chinese Herbal;
chemistry;
isolation & purification;
Flavonoids;
chemistry;
isolation & purification;
Molecular Imprinting;
Polymerization;
Polymers;
chemical synthesis;
chemistry;
Porosity;
Scutellaria baicalensis;
chemistry
- From:
China Journal of Chinese Materia Medica
2015;40(9):1718-1722
- CountryChina
- Language:Chinese
-
Abstract:
Taking mesoporous molecular sieve MCM-41 as a substrate, baicalin (BA) as template, acrylamide (AM) as the functional monomer, ethylene glycol dimethacrylate (EGDMA) as a cross-linking agent, ethanol as solvent, under thermal polymerization initiator of azobis isobutyronitrilo (AIBN) , a kind of selective recognition of baicalin surface molecularly imprinted polymer was synthesized. The surface morphologies and characteristics of the MIPs were characterized by infrared spectroscopy (IR) and transmission electron microscope (TEM). The adsorption properties of polymer microsphere for the template were tested by the dynamic adsorption equilibrium experiments and static adsorption equilibrium experiments. The experiment showed that the imprinting process was successfully and the well-ordered one-dimensional pore structure of MCM-41 was still preserved. Furthermore, molecularly imprinted polymers had higher selective ability for BA, then provided a new method for the efficient separation and enrichment of baicalin active ingredients from medicinal plants Scutellaria baicalensis.
