Study on porous starch as solid dispersion carrier of total Epimedium flavonoids.
- Author:
Hong-mei YAN
;
Xiao-bin JIA
;
Zhen-hai ZHANG
;
E SUN
;
Yi-hao XU
- Publication Type:Journal Article
- MeSH:
Calorimetry, Differential Scanning;
Chemistry, Pharmaceutical;
Drugs, Chinese Herbal;
chemistry;
Epimedium;
chemistry;
Flavonoids;
chemistry;
Porosity;
Solubility;
Starch;
chemistry;
X-Ray Diffraction
- From:
China Journal of Chinese Materia Medica
2015;40(9):1723-1726
- CountryChina
- Language:Chinese
-
Abstract:
In order to evaluate the characteristic of porous starch (PS) as the solid dispersions carrier of the total Epimedium flavonoids (TEF), the PS was used. The dissolution of icariin was selected as an indicator to analyze the differences of dissolution between TEF and its solid dispersion. TEF was characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and X-ray powder diffraction (XRD). Solid dispersion was irregular block and no powder characteristics of TEF and PS could be seen in SEM, DSC and XRD analysis suggested that TEF may be present in solid dispersion as amorphous substance. The dissolution rate of icariin has been improved significantly when the proportion of TEF and PS was 1:2. PS as a traditional solid dispersion carrier is worthy of further study.
