Quantitative and qualitative evaluation on tablets of Ginkgo biloba leaves using fingerprint and LC-MS analysis.
- Author:
Wen-lin LIANG
;
Da-wen XIE
;
Gang DING
;
Dian-hong XU
;
Yong-cheng SUN
;
Lian YUAN-PEI
;
Yan-jing LI
;
Wei XIAO
- Publication Type:Journal Article
- MeSH:
Chromatography, High Pressure Liquid;
methods;
Drugs, Chinese Herbal;
chemistry;
Ginkgo biloba;
chemistry;
Mass Spectrometry;
methods;
Plant Leaves;
chemistry;
Quality Control;
Tablets;
chemistry
- From:
China Journal of Chinese Materia Medica
2015;40(9):1738-1743
- CountryChina
- Language:Chinese
-
Abstract:
A reasonable method for the quality control of tablets of Ginkgo biloba leaves was established in this paper. The total flavonol glycosides and terpene lactones of G. biloba tablets were quantified by HPLC. Totally, 16 batches of the commercially available tablets of G. biloba leaves were determined. Among of them, 2 batches were unqualified in the content of total flavonol glycosides, and 3 batches were unqualified in the content of terpene lactones. A validated HPLC fingerprint method was established to evaluate the commercially available tablets of G. biloba leaves with the assistance of LC-MS. Sixteen batches showed the similarity of 0.763-0.989. There were 31 fingerprint chromatogram peaks were identified as flavonoids compositions by LC-MS. This provides a research idea for the quality control of tablets of G. biloba leaves.
