Study on effect of oligochitosan in promoting intestinal absorption of protoberberine alkaloids in extracts from Corydalis saxicola total alkaloids.
- Author:
Xin-yang LI
;
Hui XIE
;
Tu-lin LU
;
Yue-jiao SHI
;
Xing-de ZHANG
;
Ting LIU
- Publication Type:Journal Article
- MeSH: Animals; Berberine Alkaloids; administration & dosage; pharmacokinetics; Chitin; administration & dosage; analogs & derivatives; Corydalis; chemistry; Drugs, Chinese Herbal; administration & dosage; pharmacokinetics; Intestinal Absorption; drug effects; Intestines; drug effects; metabolism; Male; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2015;40(9):1812-1816
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of oligochitosan in promoting intestinal absorption of protoberberine alkaloids in extracts from Corydalis saxicola total alkaloids.
METHODThe in vitro single-pass intestinal perfusion model in rats was established to study the changes in absorption kinetic parameters of dehydrocavidine, berberine hydrochloride and palmatine chloride in C. saxicola total alkaloids after the addition of different concentrations oligochitosan and evaluate the effect of oligochitosan in promoting intestinal absorption of the drugs.
RESULTThe concentration of oligochitosan had different effects on the absorption rate constant (Ka) and apparent permeability coefficient (Peff) of the three active component in rat intestines. Ka and Peff in 0.5% oligochitosan group significantly increased, indicating a stronger effect in promoting the absorption.
CONCLUSIONOligochitosan has a certain effect in promoting the intestinal absorptions of protoberberine alkaloids in C. saxicola total alkaloids.