Analysis on 315 cases of clinical adverse drug reaction/event induced by gastrodin.
- Author:
Yang-yang ZHENG
;
Zhi DONG
;
Xiao-qin LU
;
Yong-peng XIA
;
Shu-bing ZHU
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Benzyl Alcohols;
administration & dosage;
adverse effects;
Child;
Child, Preschool;
China;
epidemiology;
Drug-Related Side Effects and Adverse Reactions;
epidemiology;
Drugs, Chinese Herbal;
administration & dosage;
adverse effects;
Female;
Gastrointestinal Tract;
drug effects;
Glucosides;
administration & dosage;
adverse effects;
Humans;
Male;
Middle Aged;
Retrospective Studies;
Skin;
drug effects;
Young Adult
- From:
China Journal of Chinese Materia Medica
2015;40(10):2037-2041
- CountryChina
- Language:Chinese
-
Abstract:
With patients' general situation, medication use, occurrence time of adverse drug reaction/event (ADR/ADE), clinical manifestations and prognosis as reference items, a retrospective study was made for 315 cases with ADR/ADE induced by Gastrodin in Chongqing from January 2008 to June 2014, in order to analyze the characteristics of ADR/ADE and provide reference for rational clinical medication. The results showed that among the 315 cases with ADR/ADE, 143 cases (45.4%) were males and 172 cases (54.6%) were females, most of them (74.9%) were aged above 45; 60 cases (19.0%) with ADE were caused by off-label indications and 66 cases (21.0%) with ADE were caused by over dosage; ADR/ADE cases induced by intravenous drip mainly happened within 30 min (85.5%), ADR/ADE cases induced by oral administration mainly happened within 2 h (74.4%), and all of ADR/ ADE cases induced by intramuscular injection happened within 10 min. Totally 593 ADR/ADE cases were reported, which were mainly damages in gastrointestinal system, skin and its adnexa; And 61.9% of ADR/ADE cases were newly reported. It is suggested that medical workers shall learn about the regularity and characteristics of ADR/ADE induced by gastrodin, apply it in clinic with standards, pay close attention to changes of patients' situations and attach importance to the monitoring of ADR/ADE, so as to enhance the safety of medication.
