Influence of acute hypoxia on CHL1 expression in different tissues of mice.
- Author:
Jia SUN
1
;
Xin HUANG
;
Ling-ling ZHU
;
Kui-wu WU
;
Ming FAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Brain; metabolism; Cell Adhesion Molecules; genetics; metabolism; Hypoxia; metabolism; Lung; metabolism; Male; Mice; Myocardium; metabolism; Tissue Distribution
- From: Chinese Journal of Applied Physiology 2011;27(3):280-283
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effects of acute hypoxia on the cell adhesion molecule close homologue of L1 (CHL1) expression in different brain areas and main organs (heart, lung, kidney) of mice, and provide a basis for the role of CHL1 in hypoxia injury.
METHODSMice were randomly divided into two groups (n=10): normoxia group and hypoxia group. Hypoxia group were treated by acute hypoxia (8% O2, 8 h). Protein expression changes in different tissues were evaluated by Western blot.
RESULTSIn central nervous system, CHL1 protein expressions were down-regulated in cerebral cortex, hypothalamus and brain stem by acute hypoxia and up-regulated in cerebellum. In heart and lung, CHL1 protein expression were down-regulated by acute hypoxia.
CONCLUSIONCHL1 protein expressions were changed in different tissues after acute hypoxia, which suggested CHL1 might play an important role in hypoxia damage regulation.
