Correlation between MPO 129 A/G polymorphism and severity of coronary artery disease.
- Author:
Jun-ling HU
1
;
Jian-bo XU
;
Xin ZHOU
;
Tie-min JIANG
;
Yu-ming LI
;
Mei ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Coronary Angiography; Coronary Artery Disease; blood; genetics; physiopathology; Female; Humans; Male; Middle Aged; Peroxidase; blood; genetics; Polymorphism, Genetic; Promoter Regions, Genetic; genetics; Risk Factors; Severity of Illness Index
- From: Chinese Journal of Applied Physiology 2011;27(3):306-310
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relationship between myeloperoxidase (MPO) 129 A/G promoter polymorphisms and the severity of coronary artery disease (CAD).
METHODSThe study enrolled 267 patients who had been diagnosed as coronary artery diseases by coronary angiography. The serum MPO activity was detected by colorimetric method. PCR-RFLP method was used to decide the genotypes of the patients. The severity of CAD was evaluated by the numbers of stenotic coronary arteries and the Gensini scores respectively.
RESULTSThe MPO 129 locus G and A alleles frequency were 0.893 and 0.107, respectively. No significant difference was observed in serum MPO activity between different genotypes (P > 0.05). The distribution of genotypes in different Gensini score groups had no significant difference (P > 0.05). The patients with GG genotypes were prone to develop mutivessel diseases.
CONCLUSIONNo significant correlation exists in MPO 129 locus polymorphism and serum MPO activity. The MPO 129 locus polymorphism isn't a reasonable predict factor of CAD severity.
