The effects of high fat diet and endurance exercise on the aorta wall structure of experimental animal.
- Author:
Shan-yun LIU
1
;
Yu-xiu HE
;
Hong-xia ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Aorta; ultrastructure; Atherosclerosis; etiology; prevention & control; Diet, High-Fat; adverse effects; Dietary Fats; administration & dosage; Male; Mice; Mice, Inbred C57BL; Physical Conditioning, Animal; physiology; Physical Endurance; physiology
- From: Chinese Journal of Applied Physiology 2011;27(3):315-318
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEBased on high fat diet induced the model of atherosclerosis (AS) in C57BL/6J mice, authors studied the effect of endurance exercise on the atherosclerostic formation.
METHODSForty eight 8-week-old C57BL/6J mice were divided into four groups randomly (n=12): control (group N), 12-week atherosclerosis model group(group H), 12-week atherosclerosis model plus 11-week treadmill training group (group H + E) and 22-week atherosclerosis model group (group HS). Then, we observed the effects of endurance exercise on the ultra structure of aorta by electron microscope.
RESULTSTwenty weeks of high fat diet could result in serious AS in mice while endurance exercise could significantly antagonize or restrain the occur of AS. In addition, 10 weeks of endurance exercise could alleviate the symptom of pathological changes which already happened on aorta wall.
CONCLUSIONIt indicated that endurance exercise could effectively prevent and cure AS that induced by high fat diet.
