Effect of total flavonoids from Chrysanthemun morifolium on learning and memory in aging mice.
- Author:
Pian-hong ZHANG
1
;
Hu-qiang TANG
;
Ming-zhi ZHENG
;
Ying-ying CHEN
;
Yue-liang SHEN
Author Information
- Publication Type:Journal Article
- MeSH: Aging; drug effects; physiology; Animals; Antioxidants; pharmacology; Cholinergic Fibers; physiology; Cholinergic Neurons; physiology; Chrysanthemum; chemistry; Female; Flavonoids; isolation & purification; pharmacology; Learning; drug effects; Male; Memory; drug effects; Mice; Mice, Inbred ICR
- From: Chinese Journal of Applied Physiology 2011;27(3):368-371
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of total fiavonoids from Chrysanthemun morifolium (TFCM) on learning and memory, and cholinergic system function in aging mice.
METHODSThe aging mice model was established by subcutaneous injection of D-galactose. ICR mice were divided into five groups (n=10): contrA group, model group, and TFCM groups. Mice in TFCM groups were given TFCM (50,100 or 150 mg/kg) by gastric irrigation once a day. Learning and memory ability were evaluated by Morris water maze test. The MDA content, SOD and Ach E activity were also measured.
RESULTSCompared with control group, learning and memory ability declined in the D-galactose-induced aging mice; meanwhile MDA content and AchE activity increased, SOD activity decreased. Treatment with TFCM (100, 150 mg/kg) ameliorated the decrease in learning and memory ability of aging mice. Compared with model group, TFCM (100, 150 mg/kg) could also decrease MDA content and Ach E activity, and increase SOD activity in aging mice.
CONCLUSIONTFCM may improve the learning and memory ability of aging mice. The mechanism is involved in its antioxidative characteristic and improvement of central cholinergic system function.
