Lipid peroxidation and biomechanical properties of artery in hyperlipemia rats after treating with tetrahydrobiopterin.
- Author:
Bao-Liang ZHU
1
;
Rui-Zhen YAN
;
Jiang YU
;
Yan-Jun DONG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Aorta, Thoracic; metabolism; physiopathology; Biomechanical Phenomena; drug effects; Biopterin; analogs & derivatives; therapeutic use; Hyperlipidemias; drug therapy; Lipid Peroxidation; drug effects; Male; Rats; Rats, Wistar
- From: Chinese Journal of Applied Physiology 2011;27(4):461-464
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effect of the level of lipid peroxidation and biomechanical properties after chronic treating with tetrahydrobiopterin (BH4) in thoracic aorta of hyperlipemia (HL) rats.
METHODSHL rats were given BH4 chronically. The opening angle in the zero-stress state and the relationship between pressure and diameter (P-D) of mesenteric artery were measured by computer image 8, 16, and 24 week-old respectively.
RESULTSTreating with BH4 chronically from 8 week-old in HL rats, there was a significant increase in the zero-stress state of opening angle of thoracic aorta. The P-D curve of mesenteric artery moved upward.
CONCLUSIONTreating with BH4 prevented the structure and function of artery from abnormal changing, and attenuated lipid peroxidation in HL rats.
