Synthesis and characterization of surface-modified Fe3O4 super-paramagnetic nanoparticles.
10.1007/s11596-014-1270-8
- Author:
Zhan-jie ZHANG
1
;
Jia MA
;
Shuang-bing XU
;
Jing-hua REN
;
You QIN
;
Jing HUANG
;
Kun-yu YANG
;
Zhi-ping ZHANG
;
Gang WU
Author Information
1. Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China, zhzhjie1234@163.com.
- Publication Type:Journal Article
- MeSH:
Ferric Compounds;
chemistry;
Magnetite Nanoparticles;
chemistry;
Microscopy, Electron, Transmission;
Spectroscopy, Fourier Transform Infrared;
Surface Properties;
Water;
chemistry;
X-Ray Diffraction
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2014;34(2):270-275
- CountryChina
- Language:English
-
Abstract:
Aqueous dispersion and stability of Fe3O4 nanoparticles remain an issue unresolved since aggregation of naked iron nanoparticles in water. In this study, we successfully synthesized different Fe3O4 super-paramagnetic nanoparticles which were modified by three kinds of materials [DSPE-MPEG2000, TiO2 and poly acrylic acid (PAA)] and further detected their characteristics. Transmission electron microscopy (TEM) clearly showed sizes and morphology of the four kinds of nanoparticles. X-ray diffraction (XRD) proved successfully coating of the three kinds of nanoparticles and their structures were maintained. Vibrating sample magnetometer (VSM) verified that their magnetic properties fitted for the super-paramagnetic function. More importantly, the particle size analysis indicated that Fe3O4@PAA had a better size distribution, biocompatibility, stability and dispersion than the other two kinds of nanoparticles. In addition, using CNE2 cells as a model, we found that all nanoparticles were nontoxic. Taken together, our data suggest that Fe3O4@PAA nanoaparticles are superior in the application of biomedical field among the four kinds of Fe3O4 nanoparticles in the future.
