Effects of integrins and integrin αvβ3 inhibitor on angiogenesis in cerebral ischemic stroke.
10.1007/s11596-014-1274-4
- Author:
Jia-jia BI
1
;
Li YI
Author Information
1. Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, 518036, China, alina@bjmu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Animals;
Blood Vessels;
drug effects;
physiopathology;
Blood-Brain Barrier;
drug effects;
metabolism;
physiopathology;
Humans;
Integrin alphaVbeta3;
antagonists & inhibitors;
metabolism;
Integrins;
metabolism;
Models, Biological;
Peptides, Cyclic;
pharmacology;
Stroke;
metabolism;
physiopathology;
Vascular Endothelial Growth Factor A;
metabolism
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2014;34(3):299-305
- CountryChina
- Language:English
-
Abstract:
Integrins such as αvβ3, α5β1 play a key role in angiogenesis regulation, invasion and metastasis, inflammation, wound healing, etc. The up-regulation of integrin αvβ3 after cerebral ischemic stroke can promote angiogenesis, which in turn improves functional recovery. In addition, the integrin αvβ3 inhibitor can block the blood-brain barrier (BBB) leakage induced by vascular endothelial growth factor (VEGF) and also can reduce inflammatory reaction, decrease the deposition of fibrinogen. Other studies showed that integrin αvβ3 is not essential in revascularization. Therefore, the effect of integrin αvβ3 in the whole process of brain function recovery merits further study.
