Up-regulated expression of Tim-3/Gal-9 at maternal-fetal interface in pregnant woman with recurrent spontaneous abortion.
10.1007/s11596-014-1320-2
- Author:
Jing LI
1
;
Fan-fan LI
;
Wei ZUO
;
Yuan ZHOU
;
Hai-yan HAO
;
Jing DANG
;
Min JIANG
;
Meng-zhou HE
;
Dong-rui DENG
Author Information
1. Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China, 379365840@qq.com.
- Publication Type:Clinical Trial
- MeSH:
Abortion, Spontaneous;
metabolism;
pathology;
Adolescent;
Adult;
Chorionic Villi;
metabolism;
pathology;
Female;
Galectins;
biosynthesis;
Hepatitis A Virus Cellular Receptor 2;
Humans;
Interleukin-12;
blood;
Interleukin-4;
blood;
Membrane Proteins;
biosynthesis;
Pregnancy;
Pregnancy Proteins;
biosynthesis;
Up-Regulation
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2014;34(4):586-590
- CountryChina
- Language:English
-
Abstract:
The relationship between T cell immunoglobulin domain and mucin domain protein 3 (Tim-3)/Galectin (Gal)-9 pathway and recurrent spontaneous abortion (RSA) was studied. Thirty-one pregnant women with RSA and 27 normal early gravidas were investigated to detect the levels of Tim-3 and Gal-9 in villi and deciduas by Western blotting. Meanwhile, the concentration of interleukin (IL)-4 and IL-12 in peripheral blood plasma was determined by ELISA in 25 healthy fertile non-pregnant controls, the normal early gravidas and pregnant women with RSA mentioned above, respectively. It was found that the relative expression levels of Tim-3 and Gal-9 in villi and deciduas were significantly increased in pregnant women with RSA as compared with those in the normal early gravidas. The concentration of IL-4 in peripheral blood plasma of pregnant women with RSA was lower than that of the normal early gravidas (P<0.05) and healthy fertile non-pregnant controls (P<0.05), but that of IL-2 in pregnant women with RSA was significantly higher than that of the normal early gravidas (P<0.05) and healthy fertile non-pregnant controls (P<0.05). It was suggested that the overexpression of Tim-3/Gal-9 pathway may be related to the pathogenesis of RSA.
