Change of iodine load and thyroid homeostasis induced by ammonium perchlorate in rats.
10.1007/s11596-014-1335-8
- Author:
Hong-Xia CHEN
1
;
Miao-Hong DING
;
Qin LIU
;
Kai-Liang PENG
Author Information
1. Institute of Biomedicine, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, China, hustchenhx@163.com.
- Publication Type:Journal Article
- MeSH:
Analysis of Variance;
Animals;
Catalase;
metabolism;
Dose-Response Relationship, Drug;
Homeostasis;
drug effects;
Iodine;
metabolism;
urine;
Male;
Malondialdehyde;
metabolism;
Perchlorates;
pharmacology;
Quaternary Ammonium Compounds;
pharmacology;
Radioimmunoassay;
Rats, Sprague-Dawley;
Superoxide Dismutase;
metabolism;
Thyroid Gland;
metabolism;
Thyrotropin;
blood;
Thyroxine;
blood;
Triiodothyronine;
blood
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2014;34(5):672-678
- CountryChina
- Language:English
-
Abstract:
Ammonium perchlorate (AP), mainly used as solid propellants, was reported to interfere with homeostasis via competitive inhibition of iodide uptake. However, detailed mechanisms remain to be elucidated. In this study, AP was administered at 0, 130, 260 and 520 mg/kg every day to 24 male SD rats for 13 weeks. The concentrations of iodine in urine, serum thyroid hormones levels, total iodine, relative iodine and total protein, and malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) activity in thyroid tissues were measured, respectively. Our results showed that high-dose perchlorate induced a significant increase in urinary iodine and serum thyroid stimulating hormone (TSH), with a decrease of total iodine and relative iodine content. Meanwhile, free thyroxine (FT4) was decreased and CAT activity was remarkably increased. Particularly, the CAT activity was increased in a dose-dependent manner. These results suggested that CAT might be enhanced to promote the synthesis of iodine, resulting in elevated urinary iodine level. Furthermore, these findings suggested that iodine in the urine and CAT activity in the thyroid might be used as biomarkers for exposure to AP, associated with thyroid hormone indicators such as TSH, FT4.
