Preparation of Xionggui nasal sprays and its evaluation in release in vitro and absorption in vivo.
- Author:
Yan-jun CHEN
1
;
Ri-xian JIN
;
Hong-jun YANG
;
He ZHANG
;
Jing ZENG
Author Information
- Publication Type:Journal Article
- MeSH: Absorption; Administration, Intranasal; Aerosols; Angelica sinensis; chemistry; Animals; Drug Carriers; Drug Combinations; Drug Compounding; methods; Drugs, Chinese Herbal; administration & dosage; isolation & purification; pharmacokinetics; Edetic Acid; Emulsions; Ethanolamines; Female; Ligusticum; chemistry; Male; Nasal Mucosa; metabolism; Plants, Medicinal; chemistry; Polyethylene Glycols; Polysaccharides, Bacterial; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2006;31(1):34-37
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study Xionggui nasal sprays and its evaluation in release in vitro and absorption in vivo.
METHODEstablishing the best prescription of Xionggui nasal sprays through orthogonal design methods, The in vitro release action of Xionggui nasal sprays was studied using dynamic dialyse method. The in vivo rat nasal recirculation methods were used to study the rule of Xionggui nasal sprays absorption.
RESULTThe optimum prescription was: Pemulen TR-1 0.35%, EDTA 0.2%, PEG400 1%, xanthan gum 0.2%; trolamine: right amount(adjust pH). Its release in vitro and absorption in vivo meet to Higuchi distribution.
CONCLUSIONThe preparation method of Xionggui nasal sprays was appropriate. The release of drug and its uptake was well correlated.
