Study on the water-soluble composition release of compound Danshen sustained-release tablet.
- Author:
Shen-shang ZHU
1
;
Xu-jiang YUAN
;
Yuan-xin LI
Author Information
- Publication Type:Journal Article
- MeSH: Benzofurans; analysis; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Drug Combinations; Drug Stability; Drugs, Chinese Herbal; administration & dosage; chemistry; isolation & purification; Ginsenosides; analysis; Panax; chemistry; Plants, Medicinal; chemistry; Salvia miltiorrhiza; chemistry; Solubility; Tablets
- From: China Journal of Chinese Materia Medica 2006;31(1):37-40
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study on the release of compound Danshen sustained-release tablet and the evaluate method of Chinese material medica compound sustained-release preparation.
METHODRotating basket method and HPLC were employed.
RESULTThrough the determination of 6 time-point samples, the water-soluble compositions of compound Danshen sustained-release tablet had a Well-balanced release behavior with a zero-grade release model or Higuchi release model.
CONCLUSIONCompound Danshen sustained-release tablet had a zero-grade release model. The method was rapid and stable and could be applied to evaluate the water-soluble composition release of compound Danshen sustained-release Tablet.
