Protective effects of total alkaloids from rhizoma Coptis chinensis on alcohol-induced gastric lesion in rats.
- Author:
Bei LI
1
;
Hua-rong LIU
;
Yong-quan PAN
;
Qing-song JIANG
;
Jing-chuan SHANG
;
Xian-hui WAN
;
Bai-cheng HE
;
Jun-qing YANG
;
Qi-xin ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Alkaloids; isolation & purification; pharmacology; Animals; Coptis; chemistry; Drugs, Chinese Herbal; isolation & purification; pharmacology; Ethanol; Female; Gastric Mucosa; metabolism; pathology; Male; Plants, Medicinal; chemistry; Protective Agents; isolation & purification; pharmacology; Rats; Rats, Wistar; Rhizome; chemistry; Stomach Ulcer; chemically induced; metabolism; pathology
- From: China Journal of Chinese Materia Medica 2006;31(1):51-54
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of total alkaloids(TA) from rhizoma Coptis chinensis on alcohol-induced gastric lesion in rats and the possible mechanisms.
METHODThe experimental gastric damges were established by intragastric(ig) absolute ethanol, and possible protective effects of TA given orally previously were evaluated by following parameters: gastric damage indexes, gastric juice volume, acidity, and mucus quantity. The contents of NO, MDA, *OH, and SOD activity were also measured in gastric mucosa.
RESULTTA showed significantly inhibitive effects on gastric damages induced by ig ethanol in a dose dependent manner. The effects of TA (120 mg x kg(-1)) were stronger than that of both cimitidine(70 mg x kg(-1)) and berberine(100 mg x kg(-1)), the quantity of later was equal to TA as calculated with berberine. TA significantly suppressed secretion of gastric acid caused by ethanol without clear influences on gastric juice volume and mucus secretion. TA obviously blunted ethanol-induced elevation of MDA and *OH, as well as decrease of NO level and SOD activity from gastric mucosa.
CONCLUSIONIt is suggested that the TA is a potent protective agent against ethanol-induced gastric damages. The mechanism of actions may be related with inhibiting the secretion of gastric acid and blunting the increase of MDA and *OH, as well as the decrease of NO level and SOD activity from gastric mucus.
