Pharmacokinetics study on yinhuang compound microenema in rabbits.
- Author:
San-hai QIN
1
;
Hua-gan LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Area Under Curve; Bupleurum; chemistry; Chlorogenic Acid; blood; Drug Combinations; Drugs, Chinese Herbal; administration & dosage; isolation & purification; pharmacokinetics; Enema; Female; Flavonoids; blood; Lonicera; chemistry; Male; Plants, Medicinal; chemistry; Rabbits
- From: China Journal of Chinese Materia Medica 2006;31(1):54-56
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine the parameters of pharmacokinetics in rabbits, and to provide a scientific basis for clinical application of Yinhuang compound microenema.
METHODHPLC was used to determine the concentrations of chlorogenic acid and baicalin in the plasma samples of rabbits, then analyze these data by the pharmacokinetics program 3P97 to determine the parameters of pharmacokinetics and the compartmental model of both ingredients in Yinhuang compound microenema.
RESULTBaicalin showed two compartment model in rabbits and the main parameters of pharmacokinetics were as follows: t(1/2)alpha of 0.311 h, t(1/2)beta of 1.640 h, AUC of 1.531 x 10(-2) g x h x L(-1), tmax of 0.287 h, Vd of 2.182 L. Chlorogenic acid showed two compartment model in rabbits and the main parameters of pharmacokinetics were as follows: t(1/2)alpha of 0.324 h, t(1/2)beta of 1.206 h, AUC of 2.135 x 10(-2) g x h x L(-1), tmax of 0.317 h,Vd of 2.251 L.
CONCLUSIONThe main components in Yinhuang compound microenema baicalin and chlorogenic acid are absorbed quickly and absolutely after rectal administration, which have good characters of pharmacokinetics.
