Protective effects of saponines of stem and leaf of Panax notoginseng on acute myocardial ischemia in anaesthetic dogs.
- Author:
Jian-hua FU
1
;
Xin-zhi LI
;
Xiao-hong SHANG
;
Jian-xun LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Coronary Circulation; drug effects; Dogs; Endothelins; blood; Female; Ginsenosides; isolation & purification; pharmacology; Male; Myocardial Infarction; drug therapy; physiopathology; Panax; chemistry; Plant Leaves; chemistry; Plant Stems; chemistry; Plants, Medicinal; chemistry; Protective Agents; isolation & purification; pharmacology; Random Allocation; Thromboxane B2; blood
- From: China Journal of Chinese Materia Medica 2006;31(1):62-65
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the protective effects of saponines of stem and leaf of Panax notoginseng (PNSSL) on acute myocardial ischemia in anaesthetic dogs.
METHODThe acute ischemia models were made by ligation of left anterior descending (LAD) artery. The myocardial blood flow (MBF) was determined by ultrasonic doppler. The experiments adopted epicardiogram mapping to measure the scope and degree of myocardial ischemia, quantitative histologic assay (nitroblue tetrazolium, N-BT stain) to determine the size of myocardial infarction. And the endothelin (ET) and thromboxane B2 (TXB2) were measured by radioimmunological assay.
RESULTPNSSL was showed to obviously alleviate the degree of myocardial ischemia (sigma-ST) and narrow the ischemic area indicated by N-BT staining. In addition, PNSSL could increase the MBF of ischemia section. And the treatment could inhibit the ET and TXB2 release induced by ischemia and infarction.
CONCLUSIONPNSSL demonstrated to attenuate the damage subjected to myocardial ischemia and infarction, which may be due to its function of inhibiting the ET and TXA2 release, increasing the MBF, and then improving the damaged cardiac function.
