The preotective effects of total glycosides Rubus parviflolius on cerebral ischemic in rat.
- Author:
Ji-Sheng WANG
1
;
Zong-Yin QIU
;
Yong-Peng XIA
;
Hui-Zhi LI
;
Ling-Yan REN
;
Li ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Apoptosis; drug effects; Behavior, Animal; drug effects; Brain; metabolism; pathology; Glycosides; isolation & purification; pharmacology; Infarction, Middle Cerebral Artery; metabolism; pathology; physiopathology; Male; Neuroprotective Agents; pharmacology; Plant Leaves; chemistry; Plant Stems; chemistry; Plants, Medicinal; chemistry; Rats; Rats, Sprague-Dawley; Rosaceae; chemistry
- From: China Journal of Chinese Materia Medica 2006;31(2):138-141
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the protective effects of total glycosides Rubus parviflolius (TGRP) on local cerebral ischemic.
METHODThe local cerebral ischemia in rat was made by middle cerebral artery occlusion(MACO). The infraction weight was determined by TTC stain. SOD, MDA, GSH and apoptotis were determined with different method respectively.
RESULTTGRP 20, 10 mg x kg(-1) ig markedly improved the abnormal nervous symptoms, incredsed the SOD, GSH activity and reduced contentes of MDA in brain of MACO rat, TGRP 20 mg x kg(-1) ig significantly decreased the numbers of apoptotic cells in ischemic cortex.
CONCLUSIONTGRP has protective effects against cerebral infraction, and its mechanism may be related to anti-apoptotis and free radical.
