Pharmacodynamic study of Relinqing granules on bacterial pyelonephritis model in rats.
- Author:
Meng-Lin LI
1
;
Bin LIANG
;
Jing-Wen TANG
;
Yu XIE
;
Ai-Ping ZUO
;
Feng DU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anti-Infective Agents, Urinary; isolation & purification; pharmacology; Bilirubin; urine; Drugs, Chinese Herbal; isolation & purification; pharmacology; Escherichia coli Infections; urine; Female; Glycosuria; urine; Ketones; urine; Leukocyte Count; Male; Occult Blood; Plants, Medicinal; chemistry; Polygonum; chemistry; Proteinuria; urine; Pyelonephritis; urine; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2006;31(2):153-155
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effects of Relinqing granules (powder of Polygonum capitatum extract) on the bacterial pyelonephritis model in rats.
METHODThe rat bacterial pyelonephritis model was induced by injecting the escherichia coli ATCC-25922 into kidney parenchyma. The rats were divided ramdamly into Relinqing groups(52.32, 26.16 g x kg(-1)), norflorin group (0.03 g x kg(-1)), model group and normal control group, and were given experimental drugs by gastrogavage. The contents of leucocytes (WBC), occult bloo (BLD), glucose (GLU), protein (PRO), ketones, bilirubin and urobilinagen in urine were determined.
RESULTAs compared with the model group, Relinqing granules 6.0 g x kg(-1) (crude drug 52.32 g x kg(-1)) could decrease significantly the contents of WBC and BLD in urine and, however, had no markedly effects on the other biochemical parameters of urine.
CONCLUSIONRelinqqing granule has significant effects of decreasing urine WBC and BLD on the bacterial pyolonephritis in rats.
