Isolation and structural elucidation of a bioactive saponin from tubers of Bolbostemma paniculatum.
- Author:
Hai-Feng TANG
1
;
Shu-Yu ZHANG
;
Yang-Hua YI
;
Ai-Dong WEN
;
Yue-Ping ZHAO
;
Zhong-Zhuang WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Biological Assay; Carcinoma, Hepatocellular; pathology; Cell Line, Tumor; Cell Proliferation; drug effects; Cucurbitaceae; chemistry; Erythrocytes; drug effects; Hemolysis; drug effects; Humans; K562 Cells; Liver Neoplasms; pathology; Molecular Conformation; Molecular Structure; Plant Tubers; chemistry; Plants, Medicinal; chemistry; Rabbits; Saponins; chemistry; isolation & purification; pharmacology
- From: China Journal of Chinese Materia Medica 2006;31(3):213-217
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the bioactive constituents from tubers of Bolbostemma paniculatum.
METHODCompounds were isolated by extraction and partition as well as several-chromatographic techniques guided with Pyricularia oryzae bioassay method. Their structures were determined on the basis of spectral analysis and chemical evidence.
RESULTBisdesmoside (I) was isolated as active compound causing morphological abnormality of Pyncularia oryzae mycelia and elucidated as 3-0-alpha-L-arabinopyranosyl (1-->2)-beta-D-glucopyranosyl-bayogenin-28-O-beta-D-xylopyranosyl (1-->3)-alpha-L-rhamnopyranosyl (1-->2)-alpha-L-arabinopyranoside.
CONCLUSIONI is a new natural product and exhibited significant cytotoxicity against cancer cell lines K-562 and BEL-7402, but no hemolytic activity to rabbit erythrocytes.
