Effects of different concentration extract from shenghua decoction on contractile activity of the uterine smooth muscle isolated from normal, estrogen-treated and postpartum mice.
- Author:
Ding ZHAO
1
;
Wen-Hong ZHAN
;
Lian-Huai LI
;
Feng-Zhi NIE
;
Jun-Jie JIAO
;
Yang LU
Author Information
- Publication Type:Journal Article
- MeSH: Angelica sinensis; chemistry; Animals; Dose-Response Relationship, Drug; Drug Combinations; Drugs, Chinese Herbal; administration & dosage; isolation & purification; pharmacology; Estrogens; pharmacology; Female; In Vitro Techniques; Mice; Muscle, Smooth; drug effects; Plants, Medicinal; chemistry; Postpartum Period; Uterine Contraction; drug effects; Uterus; drug effects
- From: China Journal of Chinese Materia Medica 2006;31(3):243-246
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of different concentration extract from Shenghua decoction on contractile activity of the uterine smooth muscle isolated from normal, estrogen-treated and postpartum mice.
METHODMedlab/4 s vital signal recorder was used to measure the effects of extract from Shenghua decoction (3-12 mg x mL(-1)) on contractile amplitude and frequency of the isolated uterus from normal, estrogen-treated and postpartum mice.
RESULTShenghua decoction extract (3-12 mg x mL(-1)) significantly decreased the contractile activity of the mouse isolated uterus in normal non-pregnancy and postpartum, but significantly increased that of the mouse isolated uterus treated with estrogen, and didn't show significant concentration-response relationship.
CONCLUSIONThe effects of Shenghua decoction extract on contractile activity of mouse-isolated uterus treated with estrogen cannot represent the pharmacological effects on that of in normal non-pregnancy and postpartum uterus.
