Effects of slenderstyle Acanthopanax root-bark on cyclooxygenase.
- Author:
Jian-Bo QIU
1
;
Qi-Cai LONG
;
Mei-Cun YAO
Author Information
- Publication Type:Journal Article
- MeSH: 6-Ketoprostaglandin F1 alpha; metabolism; Animals; Aorta; enzymology; Cattle; Cyclooxygenase 1; metabolism; Cyclooxygenase 2; metabolism; Dinoprostone; metabolism; Drugs, Chinese Herbal; isolation & purification; pharmacology; Eleutherococcus; chemistry; Endothelial Cells; enzymology; Female; Gastric Mucosa; enzymology; Macrophages, Peritoneal; enzymology; Male; Mice; Plant Roots; chemistry; Plants, Medicinal; chemistry; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2006;31(4):316-319
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effects of slenderstyle acanthopanax root-bark on cyclooxygenase in vivo and in vitro.
METHODContents of 6-keto-PGF1alpha in bovine aorta endothelial cells, PGE2 in mouse abdominal macrophages, and 6-keto-PGF1alpha in rat stomach tissue were determined. The ulcer index in rat gastric mucosa was measured.
RESULTCOX-1 and COX-2 were inhibited by slenderstyle acanthopanax root-bark, and the inhibitive rate of COX-2 was higher than that of COX-1 at the same concentration. Necrotic injuries in health gastric mucosa were not produced, but the injuries previously induced by the ethanol worsened.
CONCLUSIONOne of the antirheumatic mechanisms of slender-root-bark might probably be mediating through inhibition of cyclooxygenase. style acanthopanax
