Effects of total base of Sophora alopecuroides on expression of SOD, MDA, NO, MPO in rats with experimental colitis.
- Author:
Jian-Guo CHEN
1
;
Hong-Zhu DENG
Author Information
- Publication Type:Journal Article
- MeSH: Alkaloids; isolation & purification; pharmacology; Animals; Anti-Inflammatory Agents, Non-Steroidal; isolation & purification; pharmacology; Colitis; metabolism; pathology; Female; Intestinal Mucosa; metabolism; pathology; Male; Malondialdehyde; metabolism; Nitric Oxide; metabolism; Peroxidase; metabolism; Plants, Medicinal; chemistry; Random Allocation; Rats; Rats, Sprague-Dawley; Sophora; chemistry; Superoxide Dismutase; metabolism
- From: China Journal of Chinese Materia Medica 2006;31(4):323-325
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of total base of Sophora alopecuroides on expression of SOD, MDA, NO, MPO in rats with experimental colitis (UC).
METHODSD rats were randomized into 6 groups and colitis was induced by administrating 2,4,6-trinitrobenzesulphonic acid (TNB) recatlly in rats. Rats were given drug by stomach after the first day for 3 weeks, and sacrificed at 23rd day to determine the content of MDA and activities of SOD, NO, MPO in colonic mucosa, and to estimate the symptom and colonic histology.
RESULTIn UC rats, SOD was significantly decreased whereas MDA, NO, MPO were increased when compared with the normal group (P < 0.05). In all treatment groups, Sophora alopecuroides could increase SOD, decrease MDA, NO, MPO (P < 0.05), and improve the symptoms and histological damages.
CONCLUSIONThe total dose of S. alopecuroides may ameliorates or alleviate the symptoms of UC through inhibiting oxygen free radical reaction, decreasing the generation of NO and exerting anti-inflammatory effects.
