Optimization of formulation of Fufang Danshen immediate release tablet by colligation score.
- Author:
Rong-feng HU
1
;
Jia-bi ZHU
;
Dai-yin PENG
;
Ji-hui TANG
;
An ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Cellulose; Dextrins; Drug Combinations; Drug Compounding; methods; Drugs, Chinese Herbal; administration & dosage; isolation & purification; Panax; chemistry; Plants, Medicinal; chemistry; Salvia miltiorrhiza; chemistry; Solubility; Tablets
- From: China Journal of Chinese Materia Medica 2006;31(5):380-382
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo optimize the formulation of immediate release tablet.
METHODThe immediate release tablet was prepared by using dry granules. The preparation was optimized by using orthogonal design which took the flow property of granules, the hardness, the disintegrating time and the dissolution rate of the tablet as indices.
RESULTThe optimized formulation contained 40% microcrystalline cellulose, 10% sodium carboxymethyl starch and 15% dextrin. The hardness disintegrating time and T50 of the tablet were 4.5 kg, 3 min, 5 min respectively.
CONCLUSIONIt is successful to prepare on immediate release tablet using the optimized formula above.
