Studies on antiviral constituents in stems and leaves of Pithecellibium clypearia.
- Author:
Yao-lan LI
1
;
Ke-ming LI
;
Miao-xian SU
;
Kan-tong LEUNG
;
Yu-wu CHEN
;
Yong-wen ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Antiviral Agents; chemistry; isolation & purification; pharmacology; Fabaceae; chemistry; Flavonoids; chemistry; isolation & purification; pharmacology; Gallic Acid; analogs & derivatives; chemistry; isolation & purification; pharmacology; Inhibitory Concentration 50; Plant Leaves; chemistry; Plant Stems; chemistry; Plants, Medicinal; chemistry; Quercetin; chemistry; isolation & purification; pharmacology; Respiratory Syncytial Viruses; drug effects
- From: China Journal of Chinese Materia Medica 2006;31(5):397-400
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the antiviral constituents in the stems and leaves of Pithecellibium clypearia.
METHODThe constituents of P. clypearia were systematically separated with various chromatographic techniques in combination with antiviral activity monitoring. Their structures were elucidated by physical and chemical properties and spectral data.
RESULTSix compounds were isolated from P. clypearia and were identified as: tricetiflavan (5, 7, 3', 4', 5'-pentahydroxylflavan) (1), myricitrin (myricetin-3-O-alpha-L-rhamnopyranoside) (2), quercitrin (quercetin-3-O-alpha-L-rhamnopyranoside) (3), quereetin (4), methyl gallate (5) and gallic acid (6).
CONCLUSIONCompound 1 approximately 5 were obtained from this plant for the first time. Compound 4 was found to show an obvious anti-respiratory syncytial virus (RSV) activity.
