Study on the function of decoction for invigorating the kidney and improving blood circulation to thrombosis on rabbit blood stasis model.
- Author:
Xiao-ping ZHAN
1
;
Mei SUN
;
Xiao-ying JIN
;
Chen-yu JIN
;
Xi-hong XU
;
Guang-ming QIN
;
Juan BAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Blood Viscosity; drug effects; Dose-Response Relationship, Drug; Drug Combinations; Drugs, Chinese Herbal; administration & dosage; isolation & purification; pharmacology; Female; Fibrin Fibrinogen Degradation Products; metabolism; Fibrinogen; metabolism; Hematocrit; Male; Plants, Medicinal; chemistry; Plasminogen Inactivators; blood; Rabbits; Random Allocation; Thrombosis; blood; pathology; Tissue Plasminogen Activator; blood
- From: China Journal of Chinese Materia Medica 2006;31(5):411-413
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effect of decoction for invigorating the kidney and improving blood circulation to thrombosis and pathology on rabbit blood stasis model.
METHODThirty rabbits were ramdomly divided into normal group, model group, high dose group, low dose group and Xue Shuan Ning group. Tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor (PAI), fibrinogen (Fbg) and D-dimer (DD) were investigated after those rabbits had been treated. One rot was solected randomly from each group to observe pathological changes.
RESULTThere were significant differences in t-PA, PAI, Fbg and DD between normal group and other groups is very obvious (P < 0.01) . Between groups of high dose low dose Xue Shuan Ning and model, the statistical differeces were significant, as well as between groups of high dose, low dose and Xue Shuan Ning groups (P < 0.05). However, there was no statistical difference between high dose group and high dose group (P > 0.05). The pathological changes in model group were most serious, those in Xue Shuan Ning were less serious. There were slight pathological changes in high dose group and low dose group.
CONCLUSIONModels ware made successfully. High dose group and low dose group have stronger effect on thrombosis than Xue Shuan Ning group.
