Effects of Yifuning capsule on blood lipids of ovariectomized hyperlipidemia rats.
- Author:
Zhi-xia WANG
1
;
Hong-zhu DENG
;
Jian-guo CHEN
;
Pei-zhong LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Capsules; Curcuma; chemistry; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Female; Hyperlipidemias; blood; Lipase; blood; Lipids; blood; Lipoprotein Lipase; blood; Materia Medica; isolation & purification; pharmacology; Ovariectomy; Oviducts; chemistry; Random Allocation; Ranidae; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2006;31(5):414-416
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effects of Yifuning (YEN) capsule on blood lipids of ovariectomized hyperlipidemia rats.
METHODFifty-six female mature Sprague-Dawley rats were randomized into 7 groups: normal control group, model control group, diethylstilbestrol tablets (DT) group, Xuezhikang group, YFN high, middle and low dose groups. The ovariectomized rats were fed on high fat diet and administrated with the drugs for 3 weeks, then were killed and estimated body weight, liver index and five items of blood lipid (TC, TG, HDL-C, LDL-C, VLDL) by test kit. Enzyme (such as HP, LDL, and whole lipase) was detected too.
RESULTThe weight and liver index of model control group increased obviously as compared with normal group. YFN could reduce TG, TC, and LDL-C (P < 0.05) of ovariectomized hyperlipidemia rats obviously and increase HP, LDL and whole lipase (P < 0.05) on the other hand.
CONCLUSIONYFN can ameliorate blood lipids of ovariectomized hyperlipidemia rats.
