Effects and mechanism of total saponins of Psammosilene tunicoids against rheumatoid arthritis.
- Author:
Xue-yong WANG
1
;
Yuan ZHANG
;
Jian-yang XU
;
De-wen QIU
;
Lu-qi HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Arthritis, Rheumatoid; metabolism; pathology; Caryophyllaceae; chemistry; Foot; pathology; Interleukin-1; metabolism; Male; Plant Roots; chemistry; Plants, Medicinal; chemistry; Rats; Rats, Wistar; Saponins; isolation & purification; pharmacology; Tumor Necrosis Factor-alpha; metabolism
- From: China Journal of Chinese Materia Medica 2006;31(5):419-421
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the antiarthritic effects and the possible mechanism of total saponins of Psammruosilene tunicoids (TSPT) against rheumatoid arthritis (RA).
METHODAfter establishing AA rat model, the TSPT'S antiarthritic effects and mechanism against RA were studied through observing the changes of ankle swelling, arthritis index and levels of IL-1beta and TNF-alpha after medication.
RESULTTSPT could effectively inhibits articular swelling, decrease arthritis index and regulate down the content of IL-1beta and TNF-alpha in the inflammatory tissue soak of AA rats.
CONCLUSIONTSPT has good antiarthritic effects and the possible mechanism may be related to its down-regulation of IL-1beta and TNF-alpha.
