Epithelial-mesenchymal transition in prostate cancer.
- Author:
Li LIU
1
;
Li-Ling WANG
;
Xiao-Guang YU
;
Feng LIN
Author Information
1. Department of Organic Chemistry, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang 150081, China. 1227991085@qq.com
- Publication Type:Journal Article
- MeSH:
Epithelial-Mesenchymal Transition;
Humans;
Male;
Prostatic Neoplasms
- From:
National Journal of Andrology
2013;19(4):360-364
- CountryChina
- Language:Chinese
-
Abstract:
Prostate cancer (PCa) is a common disease in elderly men, its incidence ranking the second among all malignancies in males in Western countries and increasing in China in the last decade. Tumor metastasis is the main cause of death of PCa patients. In the development and progression of tumor, the tumorous cells in the infiltration area interact with their microenvironment, undergo epithelial-mesenchymal transition (EMT) and consequently cause distant metastases. So to study the role of EMT in the development and progression of tumor is of great significance for the treatment of PCa. This article reviews the relevant literature of the last 3 years and gives an overview of the factors affecting EMT in prostate cancer, aiming at a therapeutic target.
