Expression of Eag1 K(+) channel in prostate cancer and its significance.
- Author:
Yi-Qun ZHENG
1
;
Zhi-Jian LI
;
Xin GAO
;
Xiao-Bin ZHANG
;
Fa-Jiang LI
;
Ying-Jiang SHI
;
Gang LUO
;
Wei LI
Author Information
- Publication Type:Journal Article
- MeSH: Ether-A-Go-Go Potassium Channels; metabolism; Humans; Immunohistochemistry; Male; Prostate; metabolism; pathology; Prostatic Neoplasms; metabolism; pathology; RNA, Messenger; genetics; Reverse Transcriptase Polymerase Chain Reaction
- From:National Journal of Andrology 2013;19(3):205-209
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of the Eag1 K( +) channel in the prostate cancer (PCa) tissue, its correlation with the development and progression of PCa, and whether it could be a target for the diagnosis and treatment of PCa.
METHODSWe used RT-PCR and immunohistochemistry to determine the mRNA and protein expressions of the Eag1 K(+) channel in the normal peritumoral tissue of androgen-dependent PCa (ADPCa) (group A) and androgen-independent PCa (AIPCa) (group B) as well as in the tumorous tissue of ADPCa (group C) and AIPCa (group D).
RESULTSThe relative coefficients of the mRNA expression of the Eag1 K(+) channel were 0.265 +/- 0.413, 0.167 +/- 0.511, 2.673 +/- 2.988 and 2.815 +/- 2.901 in groups A, B, C and D, respectively, increased significantly in the latter two groups (P < 0.05). The positive rates of the protein expression of the Eag1 K (+) channel were significantly higher in groups C (88.9%) and D (86.7%) than in A (7.4%) and B (6.7%) (P < 0.05).
CONCLUSIONThe Eag1 K(+) channel might be involved in the pathophysiological processes of PCa, and is expected to be a valuable target for the diagnosis and treatment of PCa.
