Glutathione S-transferase polymorphisms and male infertility.
- Author:
Kai-Fa TANG
1
;
Jun-Ping XING
;
Fa SUN
Author Information
1. Department of Urology, The Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou 550004, China. doc.tangkf@hotmail.com
- Publication Type:Journal Article
- MeSH:
Genetic Predisposition to Disease;
Genotype;
Glutathione Transferase;
genetics;
Humans;
Infertility, Male;
genetics;
Male;
Polymorphism, Genetic
- From:
National Journal of Andrology
2013;19(3):266-269
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of male infertility involves the interactions between environmental and genetic factors. An individual's susceptibility to male infertility is influenced by his internal abilities of metabolizing and detoxicating endogenous and exogenous chemicals. Glutathione-S-transferases (GSTs), such as enzymes, are involved in the cellular detoxication of various physiological and xenobiotic substances. Studies show that the polymorphism of the GSTs gene is correlated with male infertility. GSTs polymorphism-related susceptibilities to male infertility were found similar but with some inconsistencies within the same community, and inconsistent with some similarities among different communities. Therefore, further studies are to be done on the differences in GSTs polymorphism-related susceptibility to male infertility in different communities.
