Human sperm chromatin damage and its determination: an update.
- Author:
Kai ZHAO
1
;
Cheng-Liang XIONG
Author Information
1. Family Planning Research Institute/Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. kaizhao@smail.hust.edu.cn
- Publication Type:Journal Article
- MeSH:
Chromatin;
genetics;
DNA Damage;
Humans;
Infertility, Male;
genetics;
Male;
Reproductive Techniques, Assisted;
Spermatozoa
- From:
National Journal of Andrology
2013;19(5):460-463
- CountryChina
- Language:Chinese
-
Abstract:
Human sperm chromatin damage is one of the common reasons for reduced male reproductive capacity, which is influenced by genetics, environment, lifestyle and other factors, as well as associated with male infertility and habitual abortion. Along with deeper insights into the structure and function of sperm chromatin, improvement and promotion of detection technology for its integrity, and wider application of assisted reproductive technology, sperm DNA damage has been recognized as an important new indicator for the evaluation of sperm quality, and has a great clinical significance in the assessment of male fertility and selection of assisted reproductive technology.
