Correlation of IPSS with IL-8 and COX-2 levels in patients with benign prostatic hyperplasia and prostatitis.
- Author:
Di-Ang CHEN
1
;
Xing-Zhi YANG
;
Pei-Hai ZHANG
;
Guang-Sen LI
;
De-Gui CHANG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Cyclooxygenase 2; metabolism; Humans; Interleukin-8; metabolism; Male; Middle Aged; Prostate; metabolism; Prostatic Hyperplasia; complications; diagnosis; metabolism; Prostatitis; complications; diagnosis; metabolism
- From: National Journal of Andrology 2013;19(6):527-530
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the correlation of International Prostate Symptom Score (IPSS) with the levels of interleukin-8 (IL-8) and cyclooxygenase-2 (COX-2) in the prostate tissue and expressed prostatic secretion (EPS) in patients with benign prostatic hyperplasia (BPH) complicated by prostatitis.
METHODSWe divided 80 BPH patients to be treated by transurethral resection of the prostate (TURP) into a simple BPH group (n = 30) and a BPH with prostatitis group (n = 50) based on the pathologic features. We statistically analyzed IPSS and the levels of IL-8 and COX-2 in EPS before surgery and the IL-8 and COX-2 levels in the prostate tissue after surgery.
RESULTSIPSS was positively correlated with the IL-8 and COX-2 levels in the prostate tissue and EPS of the BPH patients, moderately in the simple hyperplasia group (r > 0.5) and highly in the other (r > 0.8). The levels of IL-8 and COX-2 in the prostate tissue and EPS were significantly higher in the BPH with prostatitis group than in the simple BPH group (P < 0.05).
CONCLUSIONThe levels of IL-8 and COX-2 in EPS indirectly reflect those in the prostate tissue. IPSS and the levels of IL-8 and COX-2 in EPS can help determine whether BPH is complicated by histological prostatic inflammation.
