Low-dose tadalafil for erectile dysfunction following pelvic fracture-induced urethral injury: clinical observation of 42 cases.
- Author:
Yu-Xin TANG
1
;
Yu GAN
;
Xiao-Bo ZHANG
;
Xiang-Sheng ZHU
;
Xian-Zhen JIANG
;
Le-Ye HE
;
Jian-Fu YANG
Author Information
- Publication Type:Clinical Trial
- MeSH: Adult; Carbolines; administration & dosage; therapeutic use; Dose-Response Relationship, Drug; Erectile Dysfunction; drug therapy; etiology; Fractures, Bone; complications; Humans; Male; Pelvis; injuries; Tadalafil; Treatment Outcome; Urethra; injuries
- From: National Journal of Andrology 2013;19(6):539-541
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the efficacy of daily low-dose tadalafil in the treatment of erectile dysfunction (ED) following pelvic fracture-induced urethral injury (PFUI).
METHODSBased on the length of time between pelvic fracture and the patients' clinic visit, we divided 42 PFUI-caused ED patients into groups A (< 1 month), B (6-24 months) and C (> 24 months). We treated them with tadalafil at 5 mg daily for 12 weeks consecutively, followed by evaluation of the therapeutic effect using IIEF-5 questionnaire and Sexual Encounter Profile (SEP) diaries.
RESULTSThirty-four patients (83.3%) completed the investigation and all responded well to tadalafil medication. Group A showed significant differences from B and C in the increase of IIEF-5 scores and the positive rate of SEP.
CONCLUSIONDaily low-dose tadalafil helps penile rehabilitation in ED patients following PFUI, and the earlier the medication is initiated, the better the effect will be.
