Benign prostatic hyperplasia and erectile dysfunction: an update.
- Author:
Yu FAN
1
Author Information
1. Department of Andrology, Mianyang Central Hospital, Mianyang, Sichuan 821000, China. fanyu68@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Causality;
Erectile Dysfunction;
Humans;
Male;
Prostatic Hyperplasia
- From:
National Journal of Andrology
2013;19(6):572-575
- CountryChina
- Language:Chinese
-
Abstract:
Epidemiological studies have confirmed that benign prostatic hyperplasia (BPH) and erectile dysfunction (ED) are correlated, independent of age or comorbidities as diabetes. Although researchers have not yet established a direct causal relationship between the two problems, several pathophysiological factors may serve to explain it, which include the alteration in nitric oxide bioavailability, increased autonomic activity, a1-adrenergic receptor hyperactivity, imbalance of RhoA/Rho-kinase, and metabolic syndrome X. Men seeking care for BPH should always be screened for sexual function and complaints of ED. PDE5 inhibitors show promise as a future treatment for lower urinary tract symptoms secondary to BPH. Further investigation is required for future therapies and possible preventative strategies.
