Relationship between aberrant expression of miRNAs and prostate cancer.
- Author:
Jia-Yi ZHANG
1
;
Jie YANG
;
Ning-Hong SONG
Author Information
1. Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
- Publication Type:Journal Article
- MeSH:
Gene Expression Regulation, Neoplastic;
Humans;
Male;
MicroRNAs;
genetics;
Prostatic Neoplasms;
genetics;
RNA, Messenger;
genetics
- From:
National Journal of Andrology
2013;19(7):657-661
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNAs) are a kind of small non-coding single-stranded RNA molecules that negatively regulate gene expressions by binding to imperfect complementary sites in the 3 untranslated region of targeted mRNAs at the post-transcriptional level. The aberrant expression of some miRNAs has been discovered to be involved in the pathogenesis of various cancers, including prostate cancer. By analyzing miRNA expressions in prostate cancer tissues, serum and cell lines, and then investigating their mechanisms, we expect to provide some new theoretic bases for the clinical diagnosis and treatment of prostate cancer.
