Regulative mechanisms of tubular epithelial to mesenchymal transition and interventional effects of Chinese herbal medicine.
- Author:
Xue-Jiao YIN
1
;
Wei SUN
;
Yi-Gang WAN
;
Yue TU
;
Hong LIU
;
Bing-Yin YU
Author Information
1. Nanjing University of Chinese Medicine, Nanjing 210029, China. yinxue-jiao_88@sina.com
- Publication Type:Journal Article
- MeSH:
Animals;
Drugs, Chinese Herbal;
pharmacology;
Epithelial-Mesenchymal Transition;
drug effects;
Gene Expression Regulation;
drug effects;
Humans;
Kidney Tubules;
cytology;
drug effects;
metabolism;
Signal Transduction;
drug effects
- From:
China Journal of Chinese Materia Medica
2013;38(5):648-652
- CountryChina
- Language:Chinese
-
Abstract:
Epithelial to mesenchymal transition (EMT) has been proposed as a key role leading to the progressive tubulo-interstitial fibrosis (TIF). The tubular EMT is an highly regulated process involving four key steps including: loss of epithelial cell adhesion, de novo smooth muscle actin expression and actin reorganization, disruption of tubular basement membrane,and enhanced cell migration and invasion. These crucial processes are closely connected to the relative actions on many signaling pathways in EMT. Additionally, increasing evidences suggest that some Chinese herbal medicines and their extracts, such as Astragali Radix, Cordyceps, Salvia miltiorrhiza, as well as Chinese. herbal prescriptions including Astragalus Angelica mixture and Supplementing Qi and activating blood circulation decoction, could intervene the related events controlling EMT both in vitro and in vivo. Chinese herbal medicines could ameliorate TIF by intervening the course of EMT.
