Chemical constituents from Hydrangea macrophylla.

Author: Zhi-Bin WANG ¹ ; Jiang-Tao GUO ; Chun-Juan YANG ; Yong-Hai MENG ; Qiu-Hong WANG ; Bing-You YANG ; Hai-Xue KUANG
Author Information

1. Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Heilongjiang Key Laboratory of Traditional Chinese Medicine Pharmacodynamic Material Bases, Harbin 150040, China.
Publication Type:Journal Article
MeSH: Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; analysis; chemistry; isolation & purification; Flowers; chemistry; Hydrangea; chemistry
From: China Journal of Chinese Materia Medica 2013;38(5):709-713
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate chemical constituents from Chinese herbal medicine Hydrangea macrophylla.
METHODThe compounds were separated and purified by column chromatography over silica gel, ODS, and preparative HPLC. Their structures were identified by spectral methods including 1H, 13C-NMR and MS.
RESULTEleven compounds were isolated and identified as zeorin, hopane-6, 22-diol (1), botulin (2), betulinic acid (3), 2-ethyl-3-methyl-maleimide-N-beta-D-glucopyranoside (4), uridine (5), thymidine (6), adenosine (7), nicotinamide (8), methyl pyroglutamate (9), hydrangenol (10) and hydrangenol-4'-O-beta-D-glucopyranoside (11), respectively.
CONCLUSIONCompounds 14 and 7-9 were obtained from the genus Hydrangea for the first time.