Study on efficacy and mechanism of weiyangning pills against experimental gastric ulcer.
- Author:
Jing-Jing XU
1
;
Ping HUANG
;
Qing-He WU
;
Hong-Ying CAO
;
Si WEN
;
Jing LIU
Author Information
- Publication Type:Journal Article
- MeSH: Acetic Acid; adverse effects; Animals; Aspirin; adverse effects; Dinoprostone; metabolism; Drugs, Chinese Herbal; pharmacology; therapeutic use; Epidermal Growth Factor; metabolism; Female; Gastric Acid; metabolism; secretion; Ligation; adverse effects; Male; Nitric Oxide; metabolism; Rats; Rats, Sprague-Dawley; Regional Blood Flow; drug effects; Stomach Ulcer; drug therapy; etiology; metabolism; physiopathology
- From: China Journal of Chinese Materia Medica 2013;38(5):736-739
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the efficacy and mechanism of Weiyangning pills against experimental gastric ulcer.
METHODThe gastric ulcer model were established by acetic acid, water-immersion stress, aspirin induction, pyloric ligation in rats, in order to observe the effect of Weiyangning pills against experimental gastric ulcer and study its effect on the content of nitric oxide (NO) and epidermal growth factor (EGF), gastric mucosal blood flow, the content of PGE2, gastric secretion, gastric acid content and the activity of pepsin.
RESULTWeiyangning pills markedly reduced index of gastric ulcers of various types, increased the content of NO, EGF, PGE2 and gastric mucosal blood flow, inhibited gastric secretion and gastric acid content, and decreased the activity of pepsin.
CONCLUSIONWeiyangning pills has a significant effect against experimental gastric ulcer, which is related to the reduction of gastric mucosa damage factors (gastric acid and pepsin) and the increase in gastric mucosa's function as a barrier and its recovery effects, such as NO, EGF, PGE2 and gastric mucosal blood flow.
