Chemical constituents in Thunbergia from Africa.
- Author:
Feng-Jie HUNG
1
;
Jian-Xiao SONG
;
Jia-Jian LIU
;
Ai-Hu ZHAO
;
Wei JIA
Author Information
- Publication Type:Journal Article
- MeSH: Acanthaceae; chemistry; Aldehyde Reductase; antagonists & inhibitors; Animals; Nuclear Magnetic Resonance, Biomolecular; Plant Extracts; chemistry; isolation & purification; pharmacology; Plant Roots; chemistry; Rats
- From: China Journal of Chinese Materia Medica 2013;38(8):1183-1187
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the chemical compounds from the ethanol extract with inhibitory effects against aldose reductase from Thunbergia.
METHODGuided by anti-aldose reductase assay, compounds from the bioactive fraction (ethyl acetate extract) were separated and purified by various chromatographic methods including silica gel, Sephadex LH-20, and reversed-phase HPLC. Their structures were indentified based on analysis of the spectroscopic data including 1D and 2D NMR data.
RESULTEight compounds were obtained and identified as 8-hydroxy-8-methyl-9-methene-cyclopentane [7,11] -1,4, 6-trihydroxy-tetrahydronaphthalene-12-one, named as thunbergia A (1), 3,4-dihydro-4,5,8-trihydroxy-2-(3-methyl-2-butenyl) naphtha[2,3-b] oxiren-1(2H)-one (2), 8-(beta-gluco pyranosyloxy)-3,4-dihydro-2-(3-methyl-2-butenyl)naphtha [2,3-b] oxiren-1(2H)-one (3), galangin (4), quercetin (5), luteolin (6), 5,6,3',4'-tetrahydroxy -3,7-dimethoxy-flavone (7) and upeol (8).
CONCLUSIONThunbergia A was a new derivative of tetrahydronaphthalene, and compounds 2 and 3 were separated from the genus Thunbergia for the first time.
