Antagonistic effect of curcumin on lipid peroxidation of rats poisoned by paraquat.
- Author:
Hongjun LI
1
;
Yongzhi CAO
2
;
Baonan LIU
;
Lingji FENG
;
Peng LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Catalase; blood; Curcumin; pharmacology; Glutathione Peroxidase; blood; Lipid Peroxidation; drug effects; Male; Malondialdehyde; blood; Paraquat; toxicity; Random Allocation; Rats; Rats, Wistar; Superoxide Dismutase; blood
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2015;33(8):609-611
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the pathogenesis of paraquat poisoning and observe the change in lipid peroxidation of rats treated with different doses of curcumin.
METHODSA total of 50 8-week-old male Wistar rats (clean grade) were randomly divided into high-dose curcumin plus conventional treatment group, low-dose curcumin plus conventional treatment group, high-dose curcumin treatment group, poisoned group, and blank control group. Glutathione peroxidase (GSH-Px), catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA) levels in rat serum were measured at 1, 3, 7, 14, and 21 d post paraquat injection.
RESULTSCompared with the blank control group, other groups had significantly higher MDA levels but lower SOD, GSH-PX, and CAT activities. The high-dose, low-dose curcumin plus conventional treatment, and high-dose curcumin treatment groups had significantly lower serum lipid peroxidation levels compared with the poisoned group and among them the high-dose curcumin plus conventional treatment group had the most significant improvement.
CONCLUSIONCurcumin can significantly decrease serum lipid peroxidation level in rats and inhibit and delay the occurrence and progression of the damage to the body.
