Stress-induced growth-differentiation factor 15 plays an intriguing role in cardiovascular diseases.
- Author:
Hai-Tao LIU
1
;
Hai-Chang WANG
;
Ling TAO
;
Cheng-Xiang LI
;
Fei LI
;
Yu-Yang ZHANG
;
Bo-Wu LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Biomarkers; metabolism; Cardiovascular Diseases; metabolism; Growth Differentiation Factor 15; metabolism; Humans; Stress, Physiological; physiology
- From: Chinese Medical Journal 2013;126(7):1350-1354
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo provide an overview of the current knowledge of growth-differentiation factor 15 (GDF-15) in heart disease.
DATA SOURCESTo identify relevant publications, we searched PubMED database combining the textual terms of heart, cardiac, cardiovascular disease with GDF-15.
STUDY SELECTIONWell-controlled, relatively large-scale, retrospective studies as well as meaningful individual cases were all selected as materials.
RESULTSGDF-15 is a distant member of the transforming growth factor-β cytokine superfamily. In myocardium, GDF-15 is weakly expressed under physiological conditions. However, its expression level is increased in response to pathological stress. Growing evidence indicate that elevated levels of GDF-15 is a promising prognostic biomarker in cardiovascular diseases. Moreover, GDF-15 exhibits the properties of endogenous anti-hypertrophy of cardiomyocytes and protecting the heart suffering from ischemia and reperfusion insult.
CONCLUSIONVe GDF-15 may be a promising biomarker for evaluation and management of patient with cardiovascular diseases, and have potential protective properties on myocardium.
