Development in mechanisms of ischemic mitral regurgitation.
- Author:
Wei-lin HUANG
1
;
Qiang FU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Humans; Mitral Valve Insufficiency; etiology; Myocardial Ischemia; complications; Papillary Muscles; physiology; Systole; Ventricular Dysfunction, Left; complications; Ventricular Remodeling
- From: Chinese Medical Journal 2013;126(9):1766-1770
- CountryChina
- Language:English
-
Abstract:
OBJECTIVEThe clinical diagnosis and treatment of ischemia mitral regurgitation (IMR) remained difficult because of its unclear mechanisms. This paper reviews studies on the mechanisms of IMR during the last 20 years, and discusses the relevance of the various mechanisms.
DATA SOURCESData used in this review were mainly from CNKI and Pubmed in English. The search terms were "ischemia mitral regurgitation mechanism", "myocardial infarction" AND "mitral regurgitation".
STUDY SELECTIONArticles were selected if they involved mechanisms of IMR.
RESULTSIMR is one of the common complications of coronary artery disease. But currently, the clinical diagnosis and treatment of IMR remained difficult because of its unclear mechanisms.
CONCLUSIONSFor now, dominating theory of ischemic mitral regurgitation mechanisms are left ventricular remodeling, imbalance of leaflet tethering and the closing force, left ventricular dysfunction, changes in spatial structure of the annulus and the dyssynchrony of the left ventricular electromechanical activity.
