Incidence and clinical characteristics of pulmonary hypertension in patients with idiopathic pulmonary fibrosis.
- Author:
Wei YAN
;
Li-Ying PENG
;
Cheng-Jun BAN
;
Xue-Feng XU
;
Min ZHU
;
Yan LIU
;
Shu ZHANG
;
Zhen-Guo ZHAI
;
Chen WANG
;
Hua-Ping DAI
1
;
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Echocardiography, Doppler; Female; Humans; Hypertension, Pulmonary; blood; epidemiology; physiopathology; Idiopathic Pulmonary Fibrosis; blood; epidemiology; physiopathology; Incidence; Male; Middle Aged; Natriuretic Peptide, Brain; blood; Peptide Fragments; blood; Pulmonary Artery; physiopathology; Smoking
- From: Chinese Medical Journal 2015;128(7):896-901
- CountryChina
- Language:English
-
Abstract:
BACKGROUNDPulmonary hypertension (PH) frequently complicates the course of idiopathic pulmonary fibrosis (IPF) patients and is associated with significantly worse outcomes. The aim of the present study was to investigate the incidence of PH in IPF patients and evaluate the correlation between clinical parameters and systolic pulmonary artery pressure (sPAP).
METHODSHospitalized patients with IPF, who were evaluated for sPAP by Doppler echocardiography from January 2004 to December 2011, were enrolled in our study. Patients were defined as PH by an estimated sPAP > 50 mmHg and graded as PH likely, PH possible and PH unlikely, based on the 2009 European Society of Cardiology/European Respiratory Society PH Guidelines. The correlations between clinical parameters and sPAP were analyzed by multiple linear regression.
RESULTSTotally, 119 IPF patients were enrolled in our study and 28 (23.5%), 20 (16.8%) and 71 (59.7%) patients were PH likely, PH possible and PH unlikely, respectively. Borg dyspnea score was positively correlated with sPAP, r = 0.467, P < 0.001. Oxygen saturation was negatively correlated with sPAP, r = -0.416, P < 0.001. Diffusing capacity of the lung for carbon monoxide percentage predicted was negatively correlated with sPAP, r = -0.424, P = 0.003. N-terminal fragment of pro-brain natriuretic peptide and pulmonary artery width was positively correlated with sPAP, r = 0.452, P = 0.011 and r = 0.513, P < 0.001, respectively.
CONCLUSIONSThe incidence of PH in IPF patients was 23.5% in a single center of China. PH may worsen the dyspnea, right heart dysfunction and decrease the life quality of the patients with IPF.