High Levels of Antibodies to Plasmodium falciparum Liver Stage Antigen-1 in Naturally Infected Individuals in Myanmar.
10.3347/kjp.2008.46.3.195
- Author:
Hyeong Woo LEE
1
;
Sung Ung MOON
;
Yeon Joo KIM
;
Shin Hyeong CHO
;
Khin LIN
;
Byoung Kuk NA
;
Tong Soo KIM
Author Information
1. Division of Malaria and Parasitic Diseases, National Institute of Health, Korea Centers for Disease Control and Prevention, Seoul 122-701, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Plasmodium falciparum;
liver stage malaria antigen;
recombinant proteint;
antibody response;
Myanmar
- MeSH:
Animals;
Antibodies, Protozoan/*blood/immunology;
Antigens, Protozoan/*immunology;
Humans;
Immunoglobulin G/blood;
Malaria, Falciparum/blood/epidemiology/*immunology;
Myanmar/epidemiology
- From:The Korean Journal of Parasitology
2008;46(3):195-198
- CountryRepublic of Korea
- Language:English
-
Abstract:
Plasmodium falciparum liver stage antigen-1 (PfLSA-1) is one of the few antigens expressed exclusively in liver stage parasites. In this study, we evaluated the antibody responses against recombinant PfLSA-1 in naturally infected individuals in Myanmar. High levels of antibody responses (70.7%) were detected in 82 serum samples from 116 infected individuals, and IgG responses to PfLSA-1 principally composed of responses of IgG1 and IgG3 subclasses. These results show that PfLSA-1 elicits effective antibody responses in individuals infected with P. falciparum, and thus it could be not only an attractive candidate protein for vaccine development, but also a useful antigen for serodiagnosis of the infection.
