Study on the relationship between the expression of matrix metalloproteinase-9 and premature rupture of membrane as pregnant women with periodontal inflammation.
- Author:
Li-li YANG
1
;
Min CHENG
;
Wei XU
;
Lin CHENG
Author Information
- Publication Type:Journal Article
- MeSH: Female; Fetal Membranes, Premature Rupture; Humans; Inflammation; Matrix Metalloproteinase 9; Pregnancy
- From: West China Journal of Stomatology 2010;28(6):660-663
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the relationship between periodontal condition and premature rupture of membrane (PROM) in order to provide basis to keep pregnant women from oral diseases.
METHODS18 cases of preterm pregnant women with PROM (Group PPROM) and 20 cases of full-term pregnant women with PROM (Group PROM) were selected as the study group, and 28 cases of full-term normal pregnant women were selected as the control group. Everyone's plaque index (PLI), probing depth (PD) and sulcular bleeding index (SBI) were checked and recorded. Meanwhile, immunohistochemical method was used to detect the distribution and expression of matrix metalloproteinase-9 (MMP-9) in fetal membrane of cervix. The relationship between the expression of MMP-9 and PROM was analyzed.
RESULTSThe expression of MMP-9 in the pregnant women with PROM (Group PPROM and Group PROM) was higher than that in the control group. There was no relationship between the expression of MMP-9 in chorion and PD (r = 0.053, P = 0.075). The expression of MMP-9 in chorion had direct correlation with SBI (r = 0.433, P < 0.05) and PLI (r = 0.310, P < 0.05). The expression of MMP-9 in amniotic membrane hadn't dependence with PD (r = 0.077, P = 0.597), while had direct correlation with SBI (r = 0.430, P < 0.05) and PLI (r = 0.324, P < 0.05).
CONCLUSIONMMP-9 was involved in the pathological process of PROM and periodontal inflammation.
